The club's Umar Khan and Richard West also made standard, by way of the junior national track championships in Abbotsford, B.C. this summer, but they won't be making the trip.
Club head coach Bill Stephens isn't much of a numbers man, but if the times parallel last year's, Hamilton and Sayers may, in fact, be in line for some hardware.
"If you look at the results from last year, and if those results stay around the same this year, they both stand a good chance of medaling... and Andre has a good chance at winning," he said. "He's run 47.7 and I think he can run faster."
For Sayers, it's his second chance at representing his country, while the Youth Commonwealth Games marks a first for Hamilton.
Hamilton, 18, is running in the 400m, 4X100 and 4X400, while Sayers is competing in the 400m relay and the 800m.
Both hail from Scarborough and attended Birchmount Park Collegiate.
"I'm going to treat it like any other track meet, don't change anything and just enjoy it," said Hamilton, who won OFSAA gold in the 400m and finished second at the junior nationals this summer.
"I stopped setting goals for myself last year, just due to the fact that when I don't hit them it really gets to me, it could ruin the rest of the season for me, so, I just let it go how it goes."
Sayers, 17, represented his country a year ago at the world championships in the Czech Republic where he ran 1:53 as a 16 year old running against older athletes.
He finished fourth in the 800m at the junior nationals this summer to qualify for the approaching Games meet.
Sayers, whose mother ran with the Scarborough Optimists before that club evolved into the current Phoenix Athletics Association, was also a member of the gold medal-winning relay team at the nationals, along with Hamilton.
A gifted academic who attends Whitby's Sinclair Secondary, Sayers isn't sure what to expect in India. His plan is to take what he learned in the Czech Republic with him to the Youth Games.
"When I went to the World Youth championships I held my own and learned a lot about competing internationally," he said. "If I race smart, I can do very well."
"This time of year is (cross country) season so being speedy on the track is tough, but I think (Bill) and I have done a good job of training and getting in shape in less than two months."
Both Sayers and Hamilton will entertain scholarship offers when they return from India.
The boys, along with the rest of the 59-athlete team, left for the Youth Commonwealth Games Wednesday.
More than 1,300 athletes from 71 countries will participate this year.